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The patient has established cardiovascular disease with a documented history of at least one of the following: A) Previous myocardial infarction (MI) B) Previous stroke C) Symptomatic peripheral arterial disease (PAD), evidenced by one of the following: Intermittent claudication with an ankle-brachial index (ABI) less than 0.85 at rest Peripheral arterial revascularization procedure Amputation due to atherosclerotic disease D) Prior revascularization, such as coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or angioplasty, and

10.1086/525289 Physiol

COPD is characterised by chronic bronchitis and emphysema, which present with that feature persistent airway inflammation, ultimately leading to a gradual progression of irreversible airway obstruction

Initially, research on senotherapeutics focused on age-related diseases [98]

Given that reactive astrocytes can adopt either neurotoxic or neuroprotective phenotypes, both profiles present opportunities for interventions

Free radicals cause malondialdehyde levels to rise which causes oxidative stress