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Description
Several studies on different hematological malignancy cells, including AML, CLL, ALL, MM have designated that nutlins affect wild-type p53 in transcription-dependent [728,729,730] or transcription-independent manners [731,732,733,734]

This phenomenon results in symptoms such as pain, burning sensation within the muscle, inability to perform certain activities, or limitations in movement and physical activity

The recently developed MSU Crystal Deposition Quantification (MSKF) scoring system, which quantifies urate burden based on ultrasound features (e.g., double-contour sign and tophi), has been validated for distinguishing asymptomatic hyperuricemia from gout

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Dulbecco's modified Eagle's medium for cell culture, fetal bovine serum, and trypsin were purchased from Gibco (Grand Island, USA)
