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Accumulation with age of vesicular GTPases involved in endocytosis (Rab7) and lysosomal degradation (Arl8b) Small GTPases drive essential processes to clear aggregated or misfolded proteins in the cell by the process of autophagy [7]

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The strength and selectivity of this interaction can be exploited to effectively purify GST-tagged proteins

Johnson et al., 2024)

Particularly, it was recently demonstrated in a large multiethnic study that the GPx3 loci was strongly associated with a similar motor neuron disease, ALS, perhaps identifying a risk locus for neuronal disease susceptibility 20,38

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