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Patients with active eating disorders or conditions where further weight changes would be harmful should be carefully evaluated by their provider before initiating this therapy

It is a precursor of methylcobalamin and adenosylcobalamin, which are the active forms of vitamin B12

Although serum ferritin is usually a good guide to body iron stores, the correlation of body iron stores and serum ferritin may not be valid in patients on chronic renal dialysis who are also receiving iron dextran complex

In the nervous system, B12 deficiency causes symptoms affecting the nerves (numbness, tingling, tremors, balance problems) and the mind (depression, brain fog, mood swings, and, in rare cases, hallucinations and psychosis)

These individuals may need much higher doses or may not see the same results as they would with injections

Furthermore, the treatment with NMN resulted in a significant upregulation of adipose triglyceride lipase (ATGL) expression in subcutaneous fat, which is in line with the observed alterations in fat mass and adipocyte size ( + may exert beneficial effects on lipid profiles by modulating the expression of lipid-metabolizing enzymes