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This suggests that hormonal fluctuations associated with PCOS may exacerbate these conditions during the prime years of reproduction (Hassan et al., 2014)

Efferocytosis-induced lactate enables the proliferation of pro-resolving macrophages to mediate tissue repair

[PubMed: 24067275] 839

This signal 4 also presents a new opportunity for therapeutic intervention, and treatments that metabolically rewire T cells, tumor cells, or other cells in the TME have the potential to improve anti-tumor immunity

As a consequence, GSH is resistant to intracelluar degradation and is only metabolized extracellularly by organs with GGT