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Combining MOTS-c with 5-Amino-1MQ creates synergistic metabolic enhancement by targeting two distinct but complementary pathways: MOTS-c activates AMPK to increase mitochondrial biogenesis and insulin sensitivity, while 5-Amino-1MQ inhibits NNMT to preserve NAD+ levels, which fuel the very pathways MOTS-c activates

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Ongoing trials can be identified via the EU Clinical Trials Register and ClinicalTrials.gov

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10.1186/s13287-020-01691-x [DOI] [PMC free article] [PubMed] [Google Scholar] Song P., Xia X., Han T., Fang H., Wang Y., Dong F., et al

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