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World J Gastroenterol 2013

It is widely present in organisms and mainly plays a role of redox electron transfer

Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial unfolded protein response

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In addition, these changes cause a reduction of cerebral blood flow (CBF) and synaptic dysfunction with the development of neurodegeneration and cognitive impairment (Kamat et al