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"Effect of folate supplementation on folate status and health outcomes in infants, children and adolescents: a systematic review"

During prolonged periods of starvation or illness, subcutaneous fat is broken down into fatty acids (FAs) and glycerol to provide the body with essential nutrients (10)

Fractionating the daily dose into smaller, spaced-out administrations may also reduce peak plasma concentrations and minimize toxicity

Furthermore, homocysteine impairs nitric oxide production, reducing vasodilation and contributing to vascular stiffness, leaving patients at an increased risk of developing deep vein thrombosis (DVT), pulmonary embolism (PE), myocardial infarction and stroke, even at a young age (11,12)

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