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Key actions include: Activation of the folate-polyamine-AICAR pathway, triggering AMPK signaling independently of cellular energy depletion Enhanced glucose uptake in skeletal muscle via GLUT4 translocation, resembling insulin-responsive metabolic pathways Interaction with nuclear transcription factors to support antioxidant defense and control of inflammatory pathways Through these mechanisms, MOTS-c functions as a mitochondria-to-nucleus messenger, facilitating cellular adaptation to energy demands and oxidative stress

[DOI] [PubMed] [Google Scholar] Mayo-Prez S

The SYBR green channel was used to detect fluorescence as the wavelength of flavin fluorescence overlaps with that of SYBR green

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J Bionic Eng 21 , 19191948 (2024)

Plant Physiology 167, 15921603