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doi: 10.1038/sj.cdd.4401431

The results are consistently positive and the mechanistic data is compelling, but as of 2026 there are no completed Phase 3 human randomized controlled trials

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These macrophages, categorized into perivascular (pviTAM) and stromal (stiTAM) subtypes, promote angiogenesis and immunosuppression, facilitating tumor progression

Goswami D, Ghosh S, Dutta R, Ghatak D, Ranjit D, De R