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Zinc dysregulation within the endolysosomal system also intersects with cancer biology: the alcohol-deterrent and emerging anticancer agent disulfiram disrupts endolysosomal structure and raises intraluminal zinc in breast cancer cells, implicating zinc dysregulation in its cytotoxicity and suggesting that extracellular zinc availability modulates its efficacy 169

The AlOx and AlCl groups also show signs of cell death, and the degree was slightly higher in the AlOx group

USA 114 , E1528e1535 (2017)

Human experimental design Eight healthy men (age, 35.9 2.0 y

(2021, October 13)

Therefore, intact oxaliplatin is the main cytotoxic component, whereas the sulfur-Pt complexes are most likely inactive and non-cytotoxic products