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Dosefinding based on efficacytoxicity tradeoffs
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Sortilin is modified by ectodomain shedding, although the biological implications of this are not known (Evans et al., 2011)

Ice growth picked up the pace at the start of November but then slowed again, leaving plenty of open water in the Barents and Kara seas at the start of December

B.KhawajaA

GQTYCLPG was less effective, with a peptide excess of 1:40 required to induce some inhibitory effect