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Janku F, De Groot JF, Javle MM, Penas-Prado M, Shroff RT, Luthra R, Banks K, Lanman RB, Conley AP, Broaddus R, Davies MA, Kopetz S , Yung WKA, Heymach J, Fu S, Shaw KR, Meric-Bernstam F

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To enhance therapeutic precision and minimize unintended effects, future studies should explore targeted delivery methods or utilize cell-specific genetic tools to dissect irisins mechanisms of action more accurately

Clinical data reveals that cyanocobalamin is highly water-soluble and is cleared from the body rapidly

10.3748/wjg.v23.i12.2106 126 VanuytselT.TackJ.FarreR

The biggest change to current clinical practice is likely to be the advice to consider periodic monitoring of B12 levels in patients taking metformin who are at risk of deficiency, which includes a wide range of our patients living with type 2 diabetes