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Pathological myelin overload exceeding lysosomal degradation capacity induces lysosomal damage, triggering microglial senescence and pro-inflammatory cytokine release-termed the senescence-associated secretory phenotype (SASP) (85)
Currently, a fair number of them enjoy FDA acceptance with a larger number undergoing testing to gain that acceptance
J Ginseng Res 42:540548
doi: 10.1038/s41572-022-00382-6 224
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