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Elevated levels of circulating mtDNA and inflammatory cytokines such as IL-6 and IFN- have been reported in the CSF and serum of PD patients, particularly those carrying biallelic PINK1 or Parkin mutations [165]

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Gene expression analyses further show upregulation of antioxidant-response elements, reinforcing mechanistic consistency at both biochemical and transcriptional levels

LAB-mediated fermentation of natural medicines can improve immunity by activating innate immune cells, regulating immune-related cytokines, and activating the complement system (Figure 2)

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