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Annual Frequency: The original researchers restricted their evaluations to two or three short cycles per year to study the cumulative effects over time

Staus et al., 2020

Y., Chen D

& Subramanian, V

Additionally, PHMG negatively impacts liver function, heart activity (inducing procoagulant platelet activation), kidneys (causing mild hydropic changes in proximal tubules), and hematopoietic function, leading to changes in erythrocyte counts, hematocrit, and hemoglobin levels

However certain conditions, such as genetic disorders, or prolonged consumption of raw egg whites (which contain a protein called avidin that binds to biotin, inhibiting its absorption) increase the risk of biotin deficiency (NIDDKD, 2021)