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5e), for both V H domains tested, binding was observed only with wild-type 5 and not with 5-UR, strongly suggesting that the 5-UR mediates this interaction

Linecker M, Frick L, Kron P, Limani P, Kambakamba P, Tschuor C

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Regarding oxidative stress regulation, exercise can activate the Nrf2/ARE pathway, upregulating Nrf2 expression to promote SOD activity and reduce oxidative stress markers like MDA, exerting a protective effect [68-70]

Some studies have shown that human GBM cells are capable of producing the immunosuppressive factor TGF- (177), which inhibits T-cell activation, thereby weakening the immune response (178)