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These range from upregulating collagen synthesis in dermal fibroblasts to activating telomerase in aging somatic cells

Otherwise, always use bacteriostatic water

Studies indicate that in the absence of appropriate medical intervention, approximately 20% of patients with diabetic wounds will require lower limb amputation, with a subsequent one-year mortality rate of 13% post-diagnosis 19,20

PMID 25187433, retraction notice PMID 40312093), and a third (PMID 23055539) carries a 2021 Expression of Concern

If tolerated, the documented approach is to stay at the current step for the full interval before the next scheduled escalation not to leapfrog steps

Blood brings oxygen, nutrients, and growth factors