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Interestingly, HGF also reduces a caspase-independent ischemic neuronal cell death by preventing apoptosis-inducing factor (AIF) translocation downstream of poly(ADP-ribose)polymerase 1 (PARP1) and p53 (Niimura et al., 2006b)

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By 2008, however, the LPD had encountered some technical issues, delaying its official deployment until 2009

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