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The effect of acetazolamide on sleep apnea at high altitude: a systematic review and meta-analysis

PT-141

doi: 10.1158/0008-5472.CAN-09-0143

in 2022 involving 3,304 PCS patients in which a subset of individuals showed a plethora of symptoms including headaches (27.8%), fatigue (26.7%), muscle pain (23.14%), loss of smell (22.8%), altered taste (12.1%), sleep disturbances (63.1%), confusion (32.6%), focus impairment (22%), symptoms resembling PTSD (31%), feelings of depression (20%), and even thoughts of self-harm (2%) [116]

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The mitochondria have a membrane around them, and to be oxidized, the glucose or fatty acids have to get through the membrane into the mitochondria