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PMK-1 may play a similar role via distinct immune effectors to enhance lifespan suggesting that innate immunity is a key determinant of longevity

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Two structural modifications distinguish this analog from the parent tridecapeptide: substitution of Met-4 with norleucine (Nle) and inversion of Phe-7 to the D-enantiomer, both of which are widely documented in the peptide chemistry literature as means of increasing conformational and oxidative stability of the reference standard

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