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doi: 10.3389/fimmu.2025.1695321 Received 29 August 2025 Accepted 27 October 2025 Published 06 November 2025 Volume 16 - 2025 Edited by Francisco Jose Roig, Universidad San Jorge, Spain Reviewed by Pooja Rani Mina, Mayo Clinic Arizona, United States Shreyashi Pal, Birla Institute of Technology, India Updates Copyright 2025 Li, Yuan, Huang and Wang

therefore, GPx mediates the reduction of H 2 O 2 to H 2 O, and of lipid peroxides to their corresponding alcohols [202]

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Similarly, we observed increased proliferative capacity of U-1242 MG GBM cells lacking HIF1 following irradiation and enhanced sensitivity to sertraline, especially in combination with irradiation (Figure S9C)