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doi: 10.1007/s40256-018-0275-2

1 2 "Antioxidant Molecules and Redox Factors"

B12 Supplements (MAJOR EFFECT) Oral B12 Supplements: Typical dose: 1000 mcg (1 mg) Absorption: ~1-2% passively absorbed (10-20 mcg from 1000 mcg dose) Effect on serum B12: Can increase by 100-300 pg/mL within 24 hours Peak effect: 4-8 hours after oral supplement Intramuscular B12 Injections: Dose: Usually 1000 mcg Effect: Massive increase in serum B12 Can reach 1000-5000 pg/mL within hours Sustained elevation for weeks Recommendation: Stop oral supplements 3-7 days before testing (ideally 7 days) Wait 1-2 weeks after injection before testing 2

All information pertains to preclinical or published human trial data

2.1 Molecular level 2.1.1 IAA causes energy metabolism dysfunction of nerve cells GAPDH catalyzes the fifth step in glycolysis ( + binding and the catalytic domain

In a small cohort study, a non-significant association between CYP2E1 promoter RsaI restriction fragment length polymorphism and a shorter half-life and elimination rate of acetaminophen is reported [90]