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Mn can also be absorbed in small amounts through the lungs, typically under high environmental exposure (Evans and Masullo, 2023

At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions
Activation of lysosomal iron triggers ferroptosis in cancer
Research shows the compounds direct effect on circadian gene expression can help scientists understand how temporal metabolic regulation affects overall health

They reported an absolute improvement in cognition in both groups receiving losartan, paralleled with reduced systolic and diastolic blood pressure, and significant improvements in quality of life scores

10.1016/j.cger.2022.04.004 208
