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Under the ROS stimulation, the thin-sophisticated moiety (-SH) of cysteine residues is oxidized to form reversible intramolecular disulfide bonds (R-S-S-R) and sulfinyl groups (R-SOH), or irreversible sulfinic acids (R-SO 2 H) and sulfonic acids (R-SO 3 H) (Kanemura et al., 2020)

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For example, altering the levels of SAM and SAH using 3DAZ, an inhibitor decreases the cellular SAM: SAH ratio, reduces histone methylation of key genes in lipopolysaccharide (LPS)-stimulated macrophages (34)