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References 112 and 113 identify intermediates of cholesterol biosynthesis, oxysterols, as agonists of RORt (reference 114)

It plays a fundamental role in counterattacking the overproduction of reactive oxygen species (ROS) [1] that often occurs under cell injury conditions and that may lead, when uncontrolled, to the development of several types of diseases, including cancer [2]

Development of edge-activated liposomes for siRNA delivery to human basal epidermis for melanoma therapy

HFCD-fed rats displayed hyperlipidemia and increased oxidative stress, as indicated by a significant rise in blood and liver lipid profiles, an increase in plasma conjugated diene concentration, an increase in liver thiobarbituric acid reactive substances (TBARS) level, and a significant decrease in manganese superoxide dismutase (Mn-SOD) activity compared with rats fed normal diet

Horikawa K, Martin SW, Pogue SL, Silver K, Peng K, Takatsu K, et al

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