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This is not a wellness supplement or an over-the-counter product

The FEBS Journal, 276 (1), 5875

If histamine-type welts recur, a different diluent is a formulation-specific decision for the prescriber or pharmacy

10.1016/j.bbagen.2012.11.020 BBA Gen

If your skin is well hydrated the itching is considerably less then if your skin is dehydrated
If you suspect any adverse effects from B12 supplements or injections, report them through the MHRA Yellow Card scheme (yellowcard