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Autologous cell immunotherapy (IGV-001) with IGF-1R antisense oligonucleotide in newly diagnosed glioblastoma patients

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The mechanism involves RMRP binding to WT1 associated protein (WTAP) in astrocytes, reducing the expression of WTAP and the m6A modification of p53 mRNA, ultimately fostering a supportive microenvironment for neuronal axonal regeneration

These programs follow rigorous safety protocols and are staffed by clinicians who collaborate with the patients oncology team

10.1016/j.jcmgh.2019.10.006 196 KrimS