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In certain embodiments, the formulations or compositions comprise an excipient that increases the release rate of the therapeutic agent

In contrast, positional polar amine substitutions around the quinolinium core not only improved NNMT inhibition as noted previously,[17] but also enabled favorable passive and active transport across membranes (Tables 1 and 2)

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Among other mechanistic classes of halogenases, vanadium-dependent haloperoxidases (VHPOs) find applications as general-purpose halogenation biocatalysts due to their expanded substrate scope with Biegasiewicz and Gulder, among others, providing recent examples of their utility [54,55,56,57,58]