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5-Amino-1MQ operates as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme central to regulating nicotinamide metabolism and intracellular NAD+ levels

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When patients present with concerning symptoms whilst taking B12 supplements, alternative diagnoses should be considered, including allergic reactions to supplement excipients, interactions with other medications, or coincidental illness

Another study that included 256 children showed that those with a deficiency of vitamin B12 had a higher than average body mass index