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Existing studies mainly focus on iron ion deposition, reductions in neuromelanin (NM), and glial cell hyperplasia (79)

The main mechanism underlying the molecular basis of Me-ION is the inhibition of the mitochondrial oxidative phosphorylation process through the binding of the toxic metabolite of methanolformic acidwith the key enzyme of this processcytochrome c oxidase

On top of that, many food chain-breaking ATs will have lower rates of reaction with ROS and limited recycling ability (e.g., BHT and flavonoids)

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Attal N., Bouhassira D., and Colvin L., Advances and Challenges in Neuropathic Pain: A Narrative Review and Future Directions, British Journal of Anaesthesia 131, no
