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Administration of MS-275, an HDAC inhibitor, also increases expression of mGlu2 receptors, supporting the role of epigenetic mechanisms in the regulation of mGlu2 receptors [30]

et al., 1999

In obesity, changes in adipocyte size affect the metabolic and endocrine functions of adipose tissue, and infiltration by macrophages contributes to systemic inflammation and metabolic syndrome

The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations

After PLC- is activated by Gq, phosphatidylinositol 4,5- bisphosphate (PIP2) is hydrolyzed into diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) (54)

Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia , 40 , 613