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Instead, it is typically bound to sugar molecules like glucose, galactose, or rhamnose through glycosidic bonds at its 3- or 5-position hydroxyl groups, forming more stable and water-soluble derivatives such as delphinidin-3-glucoside (Sharma et al., 2021

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While the positive loop preserves Wnt activity in the matrix to maintain anagen, the negative loop assures that differences in the rate by which Wnt signaling activity in the overlying matrix decreases during late anagen are overrode to synchronize catagen induction