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The pathogenesis of tau-mediated neurodegeneration is unclear, but hyperphosphorylation, oligomerization, fibrillization, and propagation of tau pathology have been proposed as the likely pathological processes that induce the loss of function or gain of tau toxicity, which cause neurodegeneration

Months 46: Significant volume, healthier scalp

Purine analogues, such as released extracellular ATP or adenosine, activate the purinergic and adenosine receptors of immune cells, thereby promoting or suppressing immune responses [290]

The instrument was re-equilibrated at 5% B for 9 min for a total run time of 30 min

10.1016/j.jbiosc.2022.10.002

Proteomic identification of novel proteins in cortical Lewy bodies