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It can be caused by various factors such as excessive sweating, vomiting, diarrhea, or simply not drinking enough fluids

They are structurally unrelated to the soluble GSTs and the protein family has been named MAPEG (membrane-associated proteins in eicosanoid and glutathione metabolism), since some of the members act as leukotriene C and prostaglandin E synthases (Jakobsson et al., 1999)

The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

In: Shoupe D, editor

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[DOI] [PubMed] [Google Scholar] 57.Kojima C., Sakurai T., Waalkes M.P., Himeno S