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The site binds Co(II), and the Co(II) affinity for the GTP-complex is more than one thousand times stronger than for the GDP-complex ( K Co(II) ~ 30 pM versus ~100 nM, respectively)

10.1124/dmd.113.054254 17 SikiricP.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)

It suppresses NF-kB, which controls the expression of TNF-alpha along with dozens of other inflammatory mediators simultaneously

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Kipp M, Clarner T, Dang J, Copray S, Beyer C