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preparation of certain cations of the invention may occur via oxidation of quinoline (using e.g., mCPBA) followed by nitration and chlorination, respectively and further followed by amination and alkylation, respectively, as exemplified with the preparation of cation 2k (Scheme 4)

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However, while vitamin B12 supplements may help those with neurological function concerns or deficiencies, the evidence isnt strong enough to support its use as a standalone treatment for depression

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Supplementation with high doses, extended periods of supplementation, or the combination of vitamin B12 with vitamins B1, B2, or B6, were suggested as possible causal factors of acneiform eruptions [5,6]