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doi: 10.1186/s13054-023-04551-1 83 BelottoMFMagdalonJRodriguesHGVinoloMACuriRPithon-CuriTCet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Aigner E et al

Biomolecules 12 , 1646 (2022)

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In summary, we conclude that the glutathione system is the dominant mediator of antioxidative electron flux under pronounced pro-oxidative conditions across different eukaryotic kingdoms

Once a portion of the original H 2 O 2 substrate has been consumed by GPx, any remaining H 2 O 2 reacts with Fe 2+ ions from the FAS via a Fenton-type redox mechanism, oxidizing Fe 2+ to Fe +