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The aim of this study is to exploit GSH-responsive AP site capture reagent (AP probe-net), which responses to the elevated glutathione (GSH) levels in the tumor micro-environment (TME), releasing reactive alkoxyamine to trap AP sites and block the APE1-mediated BER for targeted anti-tumor activity against ATC

Hu, E., Liang, P

Glossary VDR Vitamin D receptor PP2A Protein Phosphatase 2A SASP Senescence-associated secretory phenotype EVs Extracellular vesicles Met-S metabolic syndrome T2DM type 2 diabetes mellitus CRP C-reactive protein IGF-1 Insulin/insulin-like growth factor-1 IGF-1R IGF-1 receptor ROS Reactive Oxygen Species mtROS mitochondrial ROS NADPH Nicotinamide Adenine Dinucleotide Phosphate PI3K Phosphoinositide 3-kinase IL-1 Interleukin-1 beta IL-6 Interleukin-6 TNF- Tumor Necrosis Factor-alpha GH Growth Hormone NF-B Nuclear Factor-B RAAS Renin-Angiotensin-Aldosterone System IR insulin resistance JAK/STAT Janus kinase-signal transducer and activator of transcription OXPHOS Oxidative phosphorylation NO nitric oxide eNOS endothelial nitric oxide synthase PAI-1 Plasminogen activator inhibitor-1 DAGs Diacylglycerols VCAM-1 Vascular Cell Adhesion Molecule-1 ICAM-1 Intercellular Adhesion Molecule-1 AKT/mTOR Protein Kinase B/Mammalian Target of Rapamycin ET-1 endothelin-1 VLDL very-low-density lipoproteins oxLDL oxidized low-density lipoproteins GLP-1 Glucagon-Like Peptide-1 SGLT2 sodium-dependent glucose transporter 2 AMPK Adenosine Monophosphate - Activated Protein Kinase CETP cholesteryl ester transfer protein MMPs matrix metalloproteinases VAT visceral adipose tissue PVAT perivascular adipose tissue IMCL Intramyocellular Lipids TMAO trimethylamine N-oxide MedDiet Mediterranean diet DASH Dietary Approaches to Stop Hypertension FoxO Forkhead Box O IL-6R interleukin-6 receptor sdLDL Small-dense LDL SCFAs short-chain fatty acids SPMs Specialized pro-resolving mediators References 1 Lopez-OtinCBlascoMAPartridgeLSerranoMKroemerG

Pseudomonas aeruginosa pyocyanin production reduced by quorum-sensing inhibiting nanocarriers

E.BartonJ

COPD lung tissues showed accumulation of iron with concomitant increase in lipid peroxidation