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For the open-label treatment extension period analysis, only the efficacy estimand was used due to the lack of a true placebo group

Zambrano S, Blanca AJ, Ruiz-Armenta MV, Miguel-Carrasco JL, Arvalo M, Mate A, Vzquez CM (2014) L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by up-regulating PPAR-

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It is good practice to biopsy all pigmented lesions