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Description
The increase in ROS resulted in contractile dysfunction, as indicated by decreased cell shortening and prolonged relengthening
Oxidative stress and the ageing endocrine system
P., Fung A
This leads to the formation of regenerative hepatic nodules encased in dense fibrous tissue, containing significantly higher levels of extracellular matrix proteins, particularly collagen types I, III, and IV, which hinder portal blood flow and elevate portal pressure, ultimately culminating in clinically significant portal hypertension in later disease stages (1)
A total of seven randomized controlled trials involving 450 participants were included in the meta-analysis
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