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Electrophilic agents and antioxidants induce conformational changes in Keap1, thus impeding the binding with Nrf2 leading to the consequent migration of the nuclear factor in the nucleus, where it can exert its function [22]

However, in vitro studies have some limitations, mainly concerning the low solubility, stability, and bioavailability of quercetin

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PubMed Central , Human Molecular Genetics , vol

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