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Methodes Fifty-six children following KD for at least 2 years, 27 classic KD and 29 modified atkins diet (MAD), were recruited in addition to 40 children with RE maintained on multiple AEDs

Fumarate serves as an intermediate in the Krebs cycle a key energy-producing process that takes place in the mitochondrion

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**Validation:** The redesigned sensors were validated by: * Comparing fluorescence intensity with the original sensor

Statistical analyses included one-way ANOVA and a Kruskal-Wallis test to determine significant differences in the acylcarnitine and amino acid profiles between groups

In those with an insidious course, depending on the nature and amount of damage to the kidney, symptoms such as high blood pressure, chronic fatigue, weakness, night-time urination, foul breath, increased need to drink water, and edema of the legs may occur