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About the Author Daniel Pendick, Former Executive Editor, Harvard Men's Health Watch Disclaimer: As a service to our readers, Harvard Health Publishing provides access to our library of archived content

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One major limitation of this study beyond its retrospective design is that patients who received L-carnitine had a significantly different clinical presentation

Gut microbial co-metabolite 2-methylbutyrylcarnitine exacerbates thrombosis via binding to and activating integrin 21

Health Benefits Clinically, carnitine supplementation has been shown to benefit individuals with specific deficiencies, improving energy metabolism and reducing symptoms of fatigue [9]

3.2 Host hepatic oxidation: from TMA to TMAO Following intestinal absorption, TMA is rapidly oxidized in the liver by flavin monooxygenases (FMOs), specifically FMO1 and FMO3