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Phase I reactions (primarily oxidation, reduction, and hydrolysis) structurally modify the parent compound but frequently generate reactive intermediates that can be more cytotoxic than the original molecules

This is when your immune system attacks myelin (the protective covering around your nerves)

doi: 10.1038/nature05506 132 IijimaMOrimoSTerashiHSuzukiMHayashiAShimuraHet al

Introduced in 1985, oxidative stress was found to be a source of significant cell damage that could undermine the quality of cell DNA and proteins

The most widespread explanation is that as normal cellular physiological and biochemical processes fail more frequently, dopaminergic neurons become more sensitive to toxic assault

Cerebral microvascular complications of type 2 diabetes: stroke, cognitive dysfunction, and depression