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Sections (34 m) were stained with the orceinvan Gieson method

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The possible mechanism underlying the increased oxidative stress might be mediated by complex I which is not only overexpressed in FTD3 neurons but also produces large amounts of superoxide when the matrix NADH/NAD + ratio is elevated as a result of increased TCA cycle activity (as also seen in diseased neurons)
L.et al (2013)

[DOI] [PubMed] [Google Scholar] Fukumoto J, Fukumoto I, Tamarapu Parthasarathy P, Cox R, Huynh B, Kollongod Ramanathan G, et al

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