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In histology, all kidney tissues from the mice treated with colistin showed elevated expression of the AKI markers Ngal and Kim-1, tubule dilation, loss of the brush border membranes in the proximal tubules, and the formation of protein casts throughout the kidney tissue, indicating vast tubular damage (Fig

Iranian journal of basic medical sciences

Esto permite identificar la dosis ptima individual y reconocer las seales objetivas de que el protocolo est funcionando

doi: 10.1038/nature07813

Because their metabolic pathways are damaged and the Pentose Phosphate Pathway is inherently slow, it takes an abnormally long time to regenerate that spent energy

For measurements of NOx (stable end products of NO), thiobarbituric acid (TBA) (a test measures malonaldehyde (MDA) produced due to the oxidation of fatty acids) and antioxidant glutathione (GSH) levels in plasma