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More recently, a newer generation 3-AR agonist, Mirabegron, which is approved for incontinence, showed increased BAT activity in healthy patients

doi: 10.3389/fmicb.2016.01981

Above that, excess folic acid can circulate as unmetabolized folic acid (UMFA) [17]

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[8] Similarly, patients with gout or hyperuricemia should avoid high niacin intake, as niacin (even in nicotinamide form) can raise uric acid levels and potentially trigger gout flares