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We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

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J Neurochem 72 : 20392046 Gambarana C, Ghiglieri O, Masi F, Scheggi S, Tagliamonte A, De Montis MG

pomegranate log AUC differences, using a linear model with age group, sex, and their interaction as predictors, revealed a significant age sex interaction on the intervention effect ( P = 0.004), indicating that the identified difference by age varied with participant sex

10.1002/ehf2.13634 144 TangW

Conversely, PLCAR was found to be significantly more effective for alleviating general, physical fatigue and muscular weakness (p = 0.004)
