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Furthermore, in the presence of S-nitrosylated PDI, the formation of mutant SOD1 aggregates increases in vitro (Jeon et al., 2014)

PMID 17894689

This suggests that the proliferation of this metabolic resistance marker could exacerbate malaria transmission in the field and thus have important public health consequences

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Calorie restriction also negatively influences the circulating insulin-like growth factor-1 (IGF-1) levels, thereby impacting multiple cellular pathways known for cancer proliferation